PKM2 inhibitor
CAS No. 94164-88-2
PKM2 inhibitor ( PKM2 inhibitor; MDK4882 )
Catalog No. M19274 CAS No. 94164-88-2
PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 42 | In Stock |
|
5MG | 69 | In Stock |
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10MG | 105 | In Stock |
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25MG | 194 | In Stock |
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50MG | 335 | In Stock |
|
100MG | 536 | In Stock |
|
200MG | 767 | In Stock |
|
500MG | 1152 | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NamePKM2 inhibitor
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NoteResearch use only, not for human use.
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Brief DescriptionPKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
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DescriptionMDK4882, also known as PKM2 inhibitor or compound 3k, is a PKM2 inhibitor. MDK4882 was first described in Eur J Med Chem. 2017;138:343-352. Currently there is no formal name. We temporarily name it MDK4882 for the convenience of communication, in which the last 4 digit of CAS# is used. MDK4882 displayed more potent PKM2 inhibitory activity than the reported optimal PKM2 inhibitor shikonin. MDK4882 also showed nanomolar antiproliferative activity toward a series of cancer cell lines with high expression of PKM2 including HCT116, Hela and H1299 with IC50 values ranging from 0.18 to 1.56 μM. MDK4882 exhibited more cytotoxicity on cancer cells than normal cells.
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SynonymsPKM2 inhibitor; MDK4882
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PathwayOthers
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TargetOther Targets
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RecptorPKM1; PKM2
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Research Area——
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Indication——
Chemical Information
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CAS Number94164-88-2
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Formula Weight345.48
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Molecular FormulaC18H19NO2S2
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Purity98%
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SolubilityDMSO : 5.56 mg/mL 16.09 mM; H2O : < 0.1 mg/mL
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SMILESCC1=C(C(=O)c2ccccc2C1=O)CSC(=S)N1CCCCC1
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Chemical Name(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl piperidine-1-carbodithioate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ning X, et al. Eur J Med Chem. 2017 Sep 29;138:343-352.
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