PKM2 inhibitor

CAS No. 94164-88-2

PKM2 inhibitor ( PKM2 inhibitor; MDK4882 )

Catalog No. M19274 CAS No. 94164-88-2

PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 194 In Stock
50MG 335 In Stock
100MG 536 In Stock
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Biological Information

  • Product Name
    PKM2 inhibitor
  • Note
    Research use only, not for human use.
  • Brief Description
    PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
  • Description
    MDK4882, also known as PKM2 inhibitor or compound 3k, is a PKM2 inhibitor. MDK4882 was first described in Eur J Med Chem. 2017;138:343-352. Currently there is no formal name. We temporarily name it MDK4882 for the convenience of communication, in which the last 4 digit of CAS# is used. MDK4882 displayed more potent PKM2 inhibitory activity than the reported optimal PKM2 inhibitor shikonin. MDK4882 also showed nanomolar antiproliferative activity toward a series of cancer cell lines with high expression of PKM2 including HCT116, Hela and H1299 with IC50 values ranging from 0.18 to 1.56 μM. MDK4882 exhibited more cytotoxicity on cancer cells than normal cells.
  • Synonyms
    PKM2 inhibitor; MDK4882
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PKM1; PKM2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    94164-88-2
  • Formula Weight
    345.48
  • Molecular Formula
    C18H19NO2S2
  • Purity
    98%
  • Solubility
    DMSO : 5.56 mg/mL 16.09 mM; H2O : < 0.1 mg/mL
  • SMILES
    CC1=C(C(=O)c2ccccc2C1=O)CSC(=S)N1CCCCC1
  • Chemical Name
    (3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl piperidine-1-carbodithioate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ning X, et al. Eur J Med Chem. 2017 Sep 29;138:343-352.
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